Impacto do ômega 3 no tratamento do transtorno depressivo: uma revisão da literatura

Autores

  • Caroline Kullmann Ribeiro Residência Médica em Psiquiatria Hospital São Lucas da PUCRS Porto Alegre, RS, Brasil https://orcid.org/0000-0002-2388-5812
  • Sayra Catalina Coral Castro Professora da Escola de Medicina e do Serviço de Psiquiatria da PUCRS, Porto Alegre, RS, Brasil
  • Raul Costa Fabris Curso de Formação em Psiquiatria no Hospital São Lucas da PUCRS, Porto Alegre, RS, Brasil
  • Alessandra Dalla Rosa Santini Curso de Formação em Psiquiatria no Hospital São Lucas da PUCRS, Porto Alegre, RS, Brasil

DOI:

https://doi.org/10.61661/congresso.cbmev.7.2024.112

Palavras-chave:

Ácidos Graxos Ômega-3, Transtorno Depressivo Maior, Eficácia

Resumo

Introdução: O Transtorno Depressivo Maior (TDM) é uma das principais causas de incapacidade global. No entanto, as atuais opções de tratamento para depressão permanecem limitadas pela eficácia, custo, disponibilidade, efeitos colaterais e aceitabilidade pelos pacientes. Nesse cenário, o valor dos ácidos graxos poliinsaturados (PUFAs) ômega-3 ainda segue negligenciado, embora os benefícios do seu uso já sejam amplamente apoiados pelas evidências em diversos estudos. Objetivos: Examinar evidências empíricas da associação entre os ácidos graxos ômega-3 e depressão, discutir possíveis mecanismos de ação e explorar as implicações clínicas de tais achados. Metodologia: Foi realizada revisão narrativa, com levantamento de 28 artigos publicados entre 2019 e 2024. Resultados: Os estudos demonstraram eficácia do uso de ômega-3 como terapia adjuvante para reduzir a gravidade da depressão. Contudo, a resposta ao tratamento pode variar conforme a presença de comorbidades em indivíduos deprimidos, reforçando a necessidade de estratégias de tratamento personalizadas. Conclusão: Mais investigações são necessárias para aprimorar a aplicação da suplementação de PUFAs ômega-3 e para aperfeiçoar as estratégias de medicina personalizada, aumentando, assim, a eficácia das intervenções para essa população heterogênea de pacientes. 

Biografia do Autor

Caroline Kullmann Ribeiro, Residência Médica em Psiquiatria Hospital São Lucas da PUCRS Porto Alegre, RS, Brasil

Sayra Catalina Coral Castro, Professora da Escola de Medicina e do Serviço de Psiquiatria da PUCRS, Porto Alegre, RS, Brasil

Raul Costa Fabris, Curso de Formação em Psiquiatria no Hospital São Lucas da PUCRS, Porto Alegre, RS, Brasil

Alessandra Dalla Rosa Santini, Curso de Formação em Psiquiatria no Hospital São Lucas da PUCRS, Porto Alegre, RS, Brasil

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2024-10-22

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Ribeiro CK, Castro SCC, Fabris RC, Santini ADR. Impacto do ômega 3 no tratamento do transtorno depressivo: uma revisão da literatura . Congresso Brasileiro de Medicina do Estilo de Vida [Internet]. 22º de outubro de 2024 [citado 13º de dezembro de 2024];7. Disponível em: https://publicacoes.cbmev.org.br/cbmev/article/view/112

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Saúde Mental e Manejo do Estresse