Estilo de vida e transtornos de ansiedade: BDNF, possível biomarcador?

Autores

  • Tatiana Marins Farias Faculdade de Medicina da União Metropolitana de Educação e Cultura, UNIME, Lauro de Freitas, BA, Brasil https://orcid.org/0000-0001-9319-5764
  • Sílvia Fernanda Lima de Moura Cal Faculdade de Medicina da União Metropolitana de Educação e Cultura, UNIME, Lauro de Freitas, BA, Brasil https://orcid.org/0000-0002-8396-7940
  • Rebeca Ataide de Cerqueira Martagão Gesteira Hospital da Criança, Residente de Pediatria, Salvador, BA, Brasil
  • Ana Carolina Tavares Lopes Emergencista, Clínica Médica em Hospital da Bahia e Hospital Jorge Valente, Salvador, BA, Brasil
  • Danton Ferraz de Sousa Clínica Espaço Bom Viver https://orcid.org/0000-0002-5996-001X
  • João Vitor Costa Freire Faculdade de Medicina da União Metropolitana de Educação e Cultura, UNIME, Lauro de Freitas, BA, Brasil https://orcid.org/0000-0002-3449-4358
  • Ana Julia Bernardo Faculdade de Medicina da União Metropolitana de Educação e Cultura, UNIME, Lauro de Freitas, BA, Brasil https://orcid.org/0009-0007-9445-1572

DOI:

https://doi.org/10.61661/BJLM.2023.v2.69

Palavras-chave:

BDNF, ansiedade, transtorno de ansiedade, fator neurotrófico derivado do encéfalo, neurobiologia, estilo de vida, revisão

Resumo

Introdução: Os transtornos de ansiedade (TA) são distúrbios cerebrais relacionados aos circuitos de neurotransmissores e alterações neuroanatômicas que podem ser agravados pelo estilo de vida não saudável. Por sua vez, o fator neurotrófico derivado do cérebro (BDNF), uma neurotrofina responsável pela plasticidade cerebral, está relacionado à alteração do volume em algumas estruturas cerebrais e pode ser explicado por alguns fatores do estilo de vida. Objetivo: Analisar a relação entre BDNF e TA e descrever possíveis prejuízos às funções psíquicas em indivíduos com esses transtornos. Métodos: trata-se de uma revisão integrativa da literatura de artigos publicados entre 2008 e 2018, selecionados nas bases de dados bibliográficas PubMed, SciElo e LILACS. Resultados: No total, foram selecionados 28 artigos de estudos realizados com humanos e animais. Observou-se que a relação entre níveis de BDNF e TA foi abordada, mostrando que a hipótese neurotrófica poderia contribuir para a fisiopatologia das TAs, incluindo alterações volumétricas em regiões do cérebro, compreendendo funções psíquicas. Além disso, estudos demonstraram que os níveis de BDNF podem refletir o efeito de antidepressivos ou terapia de neuromodulação, e que a exposição a fatores estressantes pode estar relacionada a indivíduos com essa variante genética serem mais vulneráveis ao desenvolvimento de TA. Conclusão: Os dados obtidos nesta pesquisa apontaram para uma relação inversa entre os níveis de BDNF e TA, e para a contribuição da hipótese neurotrófica para a neurobiologia desses distúrbios, incluindo danos às funções psíquicas. Considerando que outros estudos não mostram essa relação, novos estudos precisam ser realizados para validar uma possível associação.

Métricas

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Biografia do Autor

Tatiana Marins Farias, Faculdade de Medicina da União Metropolitana de Educação e Cultura, UNIME, Lauro de Freitas, BA, Brasil

Sílvia Fernanda Lima de Moura Cal, Faculdade de Medicina da União Metropolitana de Educação e Cultura, UNIME, Lauro de Freitas, BA, Brasil

Rebeca Ataide de Cerqueira, Martagão Gesteira Hospital da Criança, Residente de Pediatria, Salvador, BA, Brasil

Ana Carolina Tavares Lopes, Emergencista, Clínica Médica em Hospital da Bahia e Hospital Jorge Valente, Salvador, BA, Brasil

Danton Ferraz de Sousa, Clínica Espaço Bom Viver

João Vitor Costa Freire, Faculdade de Medicina da União Metropolitana de Educação e Cultura, UNIME, Lauro de Freitas, BA, Brasil

Ana Julia Bernardo, Faculdade de Medicina da União Metropolitana de Educação e Cultura, UNIME, Lauro de Freitas, BA, Brasil

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2023-10-16

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Farias TM, Cal SFL de M, Cerqueira RA de, Lopes ACT, Sousa DF de, Freire JVC, Bernardo AJ. Estilo de vida e transtornos de ansiedade: BDNF, possível biomarcador?. B J Lifestyle Med [Internet]. 16º de outubro de 2023 [citado 18º de julho de 2024];2:1-38. Disponível em: http://publicacoes.cbmev.org.br/bjlm/article/view/69

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Saúde Mental e Manejo do Estresse