Impacto do ômega 3 no tratamento do transtorno depressivo: uma revisão da literatura
DOI:
https://doi.org/10.61661/congresso.cbmev.7.2024.112Palavras-chave:
Ácidos Graxos Ômega-3, Transtorno Depressivo Maior, EficáciaResumo
Introdução: O Transtorno Depressivo Maior (TDM) é uma das principais causas de incapacidade global. No entanto, as atuais opções de tratamento para depressão permanecem limitadas pela eficácia, custo, disponibilidade, efeitos colaterais e aceitabilidade pelos pacientes. Nesse cenário, o valor dos ácidos graxos poliinsaturados (PUFAs) ômega-3 ainda segue negligenciado, embora os benefícios do seu uso já sejam amplamente apoiados pelas evidências em diversos estudos. Objetivos: Examinar evidências empíricas da associação entre os ácidos graxos ômega-3 e depressão, discutir possíveis mecanismos de ação e explorar as implicações clínicas de tais achados. Metodologia: Foi realizada revisão narrativa, com levantamento de 28 artigos publicados entre 2019 e 2024. Resultados: Os estudos demonstraram eficácia do uso de ômega-3 como terapia adjuvante para reduzir a gravidade da depressão. Contudo, a resposta ao tratamento pode variar conforme a presença de comorbidades em indivíduos deprimidos, reforçando a necessidade de estratégias de tratamento personalizadas. Conclusão: Mais investigações são necessárias para aprimorar a aplicação da suplementação de PUFAs ômega-3 e para aperfeiçoar as estratégias de medicina personalizada, aumentando, assim, a eficácia das intervenções para essa população heterogênea de pacientes.
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Copyright (c) 2024 Caroline Kullmann Ribeiro, Sayra Catalina Coral Castro, Raul Costa Fabris, Alessandra Dalla Rosa Santini
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